Classes
DEA Class; OTC
Common Brand Names; Mylanta, Mygel, DiGel, Gelusil, Rulox
- Antacids, Combos
Description
Aluminum hydroxide: Neutralizes stomach hydrochloride to form AlCl3 salt plus water; increases gastric pH
Magnesium hydroxide: Promotes bowel evacuation by causing osmotic retention of fluid, which causes the colon to distend with increased peristaltic activity; forms magnesium chloride when reacts with hydrochloric acid
Simethicone: Disperses and prevents gas pockets in the GI system by decreasing surface tension of gas bubbles
Indications
Indicated for Dyspepsia, Abdominal Bloating
Contraindications
Hypersensitivity to any component of the formulation
Adverse Effects
Aluminum hydroxide
Chalky taste
Constipation
Fecal impaction
Stomach cramps
Nausea
Vomiting
Rebound hyperacidity
Aluminum intoxication
Hypophosphatemia
Milk-alkali syndrome
Osteomalacia
Magnesium hydroxide
Diarrhea
Hypermagnesemia
Simethicone
Loose stools
Warnings
Caution in renal failure
May increase or decrease rate &/or degree of absorption of concomitantly administered oral drugs by changing GI transit time or by binding the drug
Mg-restricted diet
Similar Trade Names may have different compositions
Do not use combination product for hyperphosphatemia
Pregnancy and Lactation
Pregnancy Category: C
Lactation: excretion in milk unknown
Maximum Dosage
10-20 mL PO q4-6hr taken 1 hour before or 3 hours after meals, OR
Chew 2-4 tablets q4-6hr; not to exceed 12 tablets/24 hr
How supplied
Aluminum hydroxide/magnesium hydroxide/simethicone
liquid
- (200mg/200mg/20mg)/5mL
- (400mg/400mg/40mg)/5mL
suspension
- (225mg/200mg/25mg)/5mL
tablet, chewable
- 200mg/200mg/25mg (Gelusil)
