Classes
DEA Class; Rx
Common Brand Names; Prodrin
Analgesics, Other combo
Description
Acetaminophen: Nonnarcotic analgesic; reduces the perception of pain impulses originating from dilated cerebral vessels
Caffeine: Cranial vasoconstrictor; enhances vasoconstrictor effect of isometheptene; also used as a central stimulant for relief of headache
Isometheptene: Sympathomimetic amine that acts by constricting dilated cranial and cerebral arterioles, thus reducing the stimuli that lead to vascular headaches
Indications
Indicated in Migraine Headache, Tension Headache
Contraindications
Glaucoma
Severe renal disease
Severe hypertension
Organic heart disease
Severe hepatic disease
Coadministration or within 2 weeks of MAOIs
Adverse Effects
Rash
Transient dizziness
Warnings
Cautions with history of hypertension, peripheral vascular disease, and after recent cardiovascular events
Pregnancy and Lactation
Pregnancy Category: C Lactation: Unknown if distributed in human breast milk
Maximum Dosage
1 or 2 tablets PO at onset of headache, then 1 tablet hourly until relieved; not to exceed 5 tablets/12 hr
Pediatric
Safety and efficacy not established
How supplied
acetaminophen/caffeine/isometheptene
tablet
- 325mg/20mg/65mg
