Classes
DEA Class; OTC
Common Brand Names; Antivert, Bonine, Meni D, meclozine, Dramamine Less Drowsy Formula, VertiCalm
- Antiemetic Agents;
- Antiemetics, Antihistamine
Description
Oral piperazine-derivative sedating antihistamine; structurally similar to hydroxyzine
Used primarily as an antivertigo and antiemetic agent for symptoms associated with motion sickness
Has also been used medically in the management of vertigo in diseases affecting the vestibular apparatus
Indications
Indicated for the treatment of nausea/vomiting and dizziness associated with motion sickness.
Contraindications
Hypersensitivity
Adverse Effects
- Drowsiness
- Thickening of bronchial secretions
- Acute glaucoma attack
- Blurred vision (rare)
- Constipation
- Fatigue
- Vomiting
- Xerostomia
- Headache
- Dry mouth
- Urinary retention
Warnings
Use cautioin in obstructive genitourinary tract disease, asthma, pyloric or duodenal obstruction, prostatic hyperplasia, narrow angle glaucoma
Hepatic impairment may increase meclizine systemic exposure
Renal impairment may increase meclizine or metabolite accumulation
May impair physical or mental abilities; use caution when operating heavy machinery or performing tasks which require mental alertness
Pregnancy and Lactation
Pregnancy category: B
Lactation: Not known if excreted in milk; use caution
Maximum Dosage
100 mg/day PO for vertigo; 50 mg/day PO for nausea, vomiting, or dizziness associated with motion sickness.
100 mg/day PO for vertigo; 50 mg/day PO for nausea, vomiting, or dizziness associated with motion sickness.
50 mg/day PO for nausea, vomiting, or dizziness associated with motion sickness.
12 years: 50 mg/day PO for nausea, vomiting, or dizziness associated with motion sickness.
Less than 12 years: Safety and efficacy have not been established.
Safety and efficacy have not been established.
Safety and efficacy have not been established.
How supplied
Meclizine hydrochloride
tablet
- 12.5mg
- 25mg
- 32mg
tablet, chewable
- 25mg
