Classes
DEA Class; Rx
Common Brand Names; Nydrazid
- Antitubercular Agents
Description
Antituberculosis agent; useful when resistance to isoniazid or rifampin has been confirmed; used in combination with other agents.
Indications
Contraindications
Severe hepatic damage, acute gout, hypersensitivity
Adverse Effects
- Malaise
- Nausea
- Vomiting
- Anorexia
- Arthralgia
- Myalgia
- <1%
- Fever
- Rash
- Itching
- Acne
- Photosensitivity
- Gout
- Dysuria
- Porphyria
- Thrombocytopenia
- Hepatotoxicity
- Interstitial nephritis
Warnings
See pkg insert for complete dosage info
Pregnancy and Lactation
Pregnancy Category: C
Lactation: enters breast milk
Maximum Dosage
Dosing is based on lean body weight.
30 mg/kg/dose (Max: 3 g/dose) PO once daily or 75 mg/kg/dose PO twice weekly are the FDA-approved maximum dosages. Other regimens and maximum dosages have been used off-label.
Weighing more than 90 kg: 30 mg/kg/dose (Max: 3 g/dose) PO once daily or 75 mg/kg/dose PO twice weekly.
Weighing 76 to 90 kg: 2 g PO once daily or 5 days/week, 3 g PO 3 days/week, or 4 g PO twice weekly.
Weighing 56 to 75 kg: 1.5 g PO once daily or 5 days/week, 2.5 g PO 3 days/week, or 3 g PO twice weekly.
Weighing 40 to 55 kg: 1 g PO once daily or 5 days/week, 1.5 g PO 3 days/week, or 2 g PO twice weekly.
30 mg/kg/dose (Max: 3 g/dose) PO once daily or 75 mg/kg/dose PO twice weekly are the FDA-approved maximum dosages. Other regimens and maximum dosages have been used off-label.
Weighing more than 90 kg: 30 mg/kg/dose (Max: 3 g/dose) PO once daily or 75 mg/kg/dose PO twice weekly.
Weighing 76 to 90 kg: 2 g PO once daily or 5 days/week, 3 g PO 3 days/week, or 4 g PO twice weekly.
Weighing 56 to 75 kg: 1.5 g PO once daily or 5 days/week, 2.5 g PO 3 days/week, or 3 g PO twice weekly.
Weighing 40 to 55 kg: 1 g PO once daily or 5 days/week, 1.5 g PO 3 days/week, or 2 g PO twice weekly.
30 mg/kg/dose (Max: 3 g/dose) PO once daily or 75 mg/kg/dose PO twice weekly are the FDA-approved maximum dosages. 40 mg/kg/dose (Max: 2 g/dose) PO once daily or 5 days/week or 50 mg/kg/dose PO 3 days/week (Max: 3 g/dose) or twice weekly (Max: 4 g/dose) have been used off-label.
30 mg/kg/dose (Max: 3 g/dose) PO once daily or 75 mg/kg/dose PO twice weekly are the FDA-approved maximum dosages. 40 mg/kg/dose (Max: 2 g/dose) PO once daily or 5 days/week or 50 mg/kg/dose PO 3 days/week (Max: 3 g/dose) or twice weekly (Max: 4 g/dose) have been used off-label.
30 mg/kg/dose (Max: 3 g/dose) PO once daily or 75 mg/kg/dose PO twice weekly are the FDA-approved maximum dosages. 40 mg/kg/dose (Max: 2 g/dose) PO once daily or 5 days/week or 50 mg/kg/dose PO 3 days/week (Max: 3 g/dose) or twice weekly (Max: 4 g/dose) have been used off-label.
Safety and efficacy have not been established. 40 mg/kg/dose PO once daily has been used off-label.
How supplied
Pyrazinamide
tablet
- 500mg
