Neomycin/Polymyxin B/Gramicidin

DEA Class; Rx

Common Brand Names; Gramicidin, Neosporin Ophthalmic Solution, Neocin-PG

  • Antibiotics, Ophthalmic Combos

Aminoglycoside neomycin with polymyxin B and gramicidins A, B and C
Ophthalmic preparation; used for ophthalmic bacterial infections
Combination provides overlapping coverage against a wide range of gram-positive and gram-negative bacteria, including streptococci

Indicted for the treatment of superficial ophthalmic infection, including bacterial conjunctivitis, keratitis, keratoconjunctivitis, blepharitis, and blepharoconjunctivitis.
For ophthalmic surgical infection prophylaxis.

Aminglycoside/neomycin hypersensitivity; hypersensitivity to any product component

Hypersensitivity

Itching, swelling, and conjunctival erythema

Local transient irritation

Vesicular and maculopapular dermatitis

Angioneurotic edema

Urticaria

Watch for NEOMYCIN ocular sensitivity

Defects in visual acuity may occur with prolonged use

Posterior subpapular cataract formation, and secondary ocular infections reported with prolonged use

Prolonged use may result in overgrowth of nonsusceptible organisms including fungi; if superinfection occurs, appropriate measures should be initiated

Bacterial resistance to may develop; if purulent discharge, inflammation, or pain becomes aggravated, patient should discontinue use and consult a physician

Allergic cross-reactions may occur which could prevent use of any or all of the following antibiotics for treatment of future infections: kanamycin, paromomycin, streptomycin, and possibly gentamicin

Animal reproduction studies have not been conducted with neomycin sulfate, polymyxin B sulfate, or bacitracin

Not known whether drug is excreted in human milk; because many drugs are excreted in human milk, exercise caution when drug is administered to a nursing woman

Adults

Maximum dosage information not available.

Geriatric

Maximum dosage information not available.

Adolescents

Maximum dosage information not available.

Children

Maximum dosage information not available; safety and efficacy have not been established.

Infants

Maximum dosage information not available; safety and efficacy have not been established.

Neomycin/Polymyxin B/Gramicidin

ophthalmic solution

  • (1.75 mg/10,000/0.025 mg)/1mL (10mL)

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