Argatroban

DEA Class; Rx

Common Brand Names; Acova

• Anticoagulants, Cardiovascular; 
• Anticoagulants, Hematologic; 
• Thrombin Inhibitor

Hypersensitivity

Active major bleeding

GI bleeding (14%)

Hematuria (12%)

Chest pain (1-15%)

Hemoglobin and hematocrit decrease (10%)

Hypotension (7-10%)

Dyspnea (8%)

Fever (7%)

Sepsis (6%)

Cardiac arrest (6%)

Diarrhea (6%)

Nausea (5%)

Groin hemorrhage (5%)

Pain (5%)

Urinary tract infection (5%)

Ventricular tachycardia (5%)

Bradyarrhythmia (4.5%)

Infection (4%)

Vomiting (2.6-4%)

Intracranial hemorrhage (1-4%)

Myocardial infarction (3.5%)

Hemoptysis (3%)

Nephrotoxicity (3%)

Cough (3%)

Atrial fibrillation (3%)

Brachial hemorrhage (2%)

Major GI hemorrhage (1-2%)

Angina (1.8%)

Coronary arterial hemorrhage (1.8%)

Coronary artery thrombosis (1.8%)

Monitor therapy with aPTT

Use caution in hepatic impairment; achievement of steady-state aPTT levels may take longer and require more argatroban dose adjustments in patients with hepatic impairment compared to patients with normal hepatic function; avoid use of high doses in patients undergoing percutaneous coronary intervention (PCI) who have clinically significant hepatic disease

Patients with illnesses that reduce clearance may require dose reduction

Safety and efficacy of concomitant administration with thrombolytic agents not established

Discontinue parenteral anticoagulant therapy prior to initiating treatment

Limited data from published literature and postmarketing reports do not suggest an association between argatroban and adverse fetal developmental outcomes; there are risks to mother associated with untreated thrombosis in pregnancy and a risk of hemorrhage in mother and fetus associated with use of anticoagulants

There are no data on presence in human milk, or effects on milk production; it is present in rat milk; developmental and health benefits of breastfeeding should be considered along with mother’s clinical need for therapy and any potential adverse effects on breastfed infant from therapy or from underlying maternal condition