Betaxolol

Brands

DEA Class;  Rx

Common Brand Names; Kerlone (DSC), Betoptic, Betoptic S

  • Beta-Blockers, Beta-1 Selective
  • Antiglaucoma, Beta-Blockers

Beta-1-selective adrenergic antagonist; oral and ophthalmic forms available; does not have ISA or membrane-stabilizing activity; selectivity for the beta-1-receptor makes it a preferred agent in patients with bronchospastic pulmonary disease; used for hypertension and glaucoma.

Indicated for the treatment of hypertension.

For the treatment of chronic open-angle glaucoma and ocular hypertension.
NOTE: Beta-blockers are generally less effective in the treatment of angle-closure glaucoma than for open angle-glaucoma. 

Sinus bradycardia, 2°/3° heart block, cardiogenic shock, overt cardiac failure, hypersensitivity, sick sinus syndrome without permanent pacemaker

  • Fatigue (2-10%)
  • Bradycardia (6-8%)
  • Chest pain (2-7%)
  • Dyspepsia (2-5%)
  • Lethargy (3%)
  • Cold extremeties (2%)
  • Diarrhea (2%)
  • Dyspnea (2%)
  • Edema (2%)
  • Palpitation (2%)
  • Pharyngitis (2%)
  • Angina
  • Arrhythmia
  • Flushing
  • Depression
  • Fever
  • Hallucinations
  • Malaise
  • Neuropathy
  • Rash
  • Diabetes
  • Hyperglycemia
  • Anemia
  • Hypercholesterolemia
  • Hyperlipidemia
  • Leukocytosis
  • cataracts

Bronchospastic disease, cerebrovascular insufficiency, CHF, cardiomegaly, DM, hyperthyroidism/thyrotoxicosis, liver disease, renal impairment, peripheral vascular disease (potential risk of reduced placental perfusion, fetal bradycardia, hypoglycemia), use in pheochromocytoma, IDDM

Surgery/Anesthesia: Chronically administered beta-blockers should not be routinely withdrawn prior to major surgery; however, impaired ability of the heart to respond to reflex adrenergic stimuli may augment the risks of general anesthesia and surgical procedures

Pregnancy Category: C

Lactation: excreted in milk; use caution

Adults

20 mg/day PO; 4 drops/day 0.5% ophthalmic solution or 2 drops/day 0.25% ophthalmic suspension in each affected eye.

Elderly

20 mg/day PO; 4 drops/day 0.5% ophthalmic solution or 2 drops/day 0.25% ophthalmic suspension in each affected eye.

Adolescents

Safety and efficacy of oral and 0.5% ophthalmic solution have not been established; 2 drops/day 0.25% ophthalmic suspension in each affected eye.

Children

Safety and efficacy of oral and 0.5% ophthalmic solution have not been established; 2 drops/day 0.25% ophthalmic suspension in each affected eye.

Betaxolol hydrochloride

tablet

  • 10mg
  • 20mg

ophthalmic solution

  • 0.5% (Betoptic)

ophthalmic suspension

  • 0.25% (Betoptic S)
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