Classes
DEA Class; Rx
Common Brand Names; Clorpres
- Thiazide Combos
Description
Combination thiazide diuretic (chlorthalidone) and centrally acting alpha2 adrenergic agonist (clonidine).
Used for hypertension, but not for initial therapy; used if fixed dose represents effective dosages for the patient after titration.
The fixed combination may be more convenient than taking each drug individually.
Indications
Indicated for the treatment of hypertension.
NOTE: Clonidine; chlorthalidone fixed combination therapy is not indicated for initial antihypertensive therapy. The initial dose must be titrated to the individual patient. If the fixed combination represents the individual dosages required for the patient, its use may be more convenient in patient management.
Contraindications
Hypersensitivity to either component or sulfonamide derivatives
Adverse Effects
No adverse effects specific to the combination have been observed; adverse effects limited to those previously reported with clonidine and chlorthalidone
Clonidine
- Orthostatic hypotension
- Bradycardia
- Syncope
- Arrhythmia
- Chest pain
- Atrioventricular block
- Flushing
- Drowsiness
- Fatigue
- Malaise
- Rash
- Anorexia, weight gain
- Dry mouth
- Nausea/vomiting
- Abnormal LFTs
Chlorthalidone
- Blurred vision, xanthopsia
- Constipation
- Diarrhea
- Dizziness
- Electrolyte abnormalities
- Headache, vasculitis
- Hyperglycemia
- Hyperuricemia
- Hypotension
- Impotence
- Loss of appetite
- Muscular spasticity, restlessness
- Nausea/vomiting
- Paresthesia
- Photosensitivity, phototoxicity
Warnings
Bronchospastic disease
DM, hyperuricemia or gout, hypotension, SLE
Chlorthalidone may cause fluid or electrolyte imbalance including hyponatremia, hypochloremic alkalosis, or hypokalemia
History of depression
Liver disease
May aggravate digitalis toxicity
Patients allergic to sulfa may show cross-sensitivity
May impair ability to perform hazarous tasks
Risk of male sexual dysfunction
Renal impairment
Severe coronary insufficiency, recent MI, conduction disturbances, cerebrovascular disease, chronic renal failure, Raynaud’s disease, thromboangiitis obliteran
Sudden cessation of clonidine treatment has resulted in subjective symptoms such as nervousness, agitation and headache, accompanied or followed by a rapid rise in blood pressure and elevated catecholamine concentrations in the plasma
Pregnancy and Lactation
Pregnancy Category: C
Lactation: excreted in breast milk, use caution
Maximum Dosage
0.6 mg/day PO clonidine; 30 mg/day PO chlorthalidone when used in this combination.
0.6 mg/day PO clonidine; 30 mg/day PO chlorthalidone when used in this combination.
Safety and efficacy have not been established.
Safety and efficacy have not been established.
Use not established.
Use not established.
How supplied
Clonidine hydrochloride/Chlorthalidone
tablet
- 0.1mg/15mg
- 0.2mg/15mg
- 0.3mg/15mg
