Classes
DEA Class; Rx
Common Brand Names; Phospholine Iodide
- Miotics, Cholinesterase Inhibitors;
- Antiglaucoma, Miotics
Description
Ophthalmic cholinesterase-inhibitor miotic agent
Used in adults to decrease intraocular pressure; used in pediatric patients to diagnose and treat concomitant esotropias with a significant accommodative component
Contraindicated in patients with active uveal inflammation, angle-closure glaucoma without iridectomy, or a hypersensitivity to the drug
Indications
For the treatment of increased intraocular pressure.
For the diagnosis and treatment of strabismus of the accommodative esotropia type.
For the treatment of accommodative strabismus.
Contraindications
Hypersensitivity
Active uveitis
Angle-closure glaucoma without iridectomy
Relative: history of retinal detachment; quiescent/history of uveitis
Adverse Effects
Burning
Bradycardia
Flushing
Hypotension
Stinging
Lacrimation
Iris cyst formation
Diarrhea
Nausea
Vomiting
Blurred vision
Ciliary redness
Increased intraocular pressure
Miosis
Myopia
Uveitis activation
Lens opacities
Retinal detachment
Lid muscle twitching
Warnings
Use with caution, if at all, in patients with marked vagotonia, bronchial asthma, spastic gastrointestinal disturbances, peptic ulcer, pronounced bradycardia and hypotension, recent myocardial infarction, epilepsy, parkinsonism, and other disorders that may respond adversely to vagotonic effects
Concomitant cholinergic drugs (succinylcholine, systemic myasthenia gravis drugs)
Potential for conjunctival thickening, retinal detachment, lens opacity; use with caution, where there is prior history of retinal detachment
Temporary discontinuance of medication necessary if cholinergic side-effects, including hyperhidrosis, sialorrhea, urinary incontinence, diarrhea, muscle weakness, cardiac irregularities, or respiratory difficulties occur
Do not use more frequently than q12hr
Few weeks of therapy may depress plasma and erythrocyte cholinesterase levels
Pregnancy and Lactation
Pregnancy Category: C
Lactation: Discontinue drug or do not nurse
Maximum Dosage
2 drops/day per affected eye.
2 drops/day per affected eye.
1 drop/day per affected eye.
1 drop/day per affected eye.
