Fenoprofen

DEA Class; Rx

Common Brand Names; Nalfon

NSAIDs

Propionic acid NSAID; has antipyretic and analgesic properties; for RA, OA, and mild to moderate pain; causes an increased risk of serious gastrointestinal adverse effects; may cause an increased risk of serious cardiovascular events; use lowest effective dose for the shortest possible duration.

For the treatment of mild pain and moderate pain.

For the treatment of osteoarthritis or rheumatoid arthritis.

For migraine prophylaxis.

Absolute: ASA allergy

Relative: bleeding disorders, duodenal/gastric/peptic ulcer, renal impairment, stomatitis, SLE, ulcerative colitis, upper GI disease, late pregnancy (may cause premature closure of ductus arteriosus)

>10%

Dyspepsia (10.3%)

Somnolence

Increased LFT

1-10%

Abdominal pain

Anemia

Diarrhea

Dizziness

Edema

Headache

Constipation

Confusion

Tremor

Sweating

Tinnitus

Use caution in asthma (bronchial), cardiac disease, CHF, hepatic impairment, HTN

Long-term administration of NSAIDs may result in renal papillary necrosis and other renal injury; patients at greatest risk include the elderly, or those with impaired renal function, hypovolemia, heart failure, liver dysfunction, salt depletion, and individuals taking diuretics, ACE inhibitors, or ARBs

Pregnancy; Data from observational studies regarding other potential embryofetal risks of NSAID use in women in the first or second trimesters of pregnancy are inconclusive

3,200 mg/day PO.

3,200 mg/day PO.

Safety and efficacy have not been established.

Safety and efficacy have not been established.

Safety and efficacy have not been established.

Safety and efficacy have not been established.

Capsule

• 200mg
• 400mg

Tablets

• 600mg